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Pfizer CEO Says A Fourth Vaccine Dose Might Be Needed But It's 'Wait & See' With Omicron

"We may need it faster," he said.

First it was two doses of Pfizer vaccine to be fully immunized. Then the drug-maker suggested that three doses are needed to get the best protection against the Omicron variant.

Now, Pfizer's CEO is floating the idea of a fourth shot to keep COVID-19 at bay.

Pfizer chief executive Albert Bourla raised the possibility that a fourth dose of the vaccine might be needed in the future, less than a day after his company released promising results about Omicron and Dose No. 3.

Bourla told CNBC's Squawk Box that "real-world data" will show how well a third dose covers Omicron, and for how long. Then he brought up the idea of a second booster.

"I think we will need a fourth dose," Bourla said. He also suggested that the booster could come 12 months after Dose No. 3, if not sooner.

"With Omicron we need to wait and see because we have very little information," he said. "We may need it faster."

The most well-off countries in the world are just starting to hand out third doses of the vaccine, while other parts of the world are struggling to buy and distribute enough vaccine for two doses.

Pfizer and its vaccine-making partner, BioNTech, announced on Wednesday that three doses seem to "maximize" protection against Omicron, the latest heavily-mutated variant of the coronavirus.

Their early lab results showed that a third shot boosted protection "25-fold" when compared to two doses, although two doses still provided some protection from symptoms.

Omicron has only been on the world's radar for less than three weeks at this point, and many studies are underway to determine exactly how severe and transmissible it might be. Pfizer and others have also been looking into whether current vaccines offer the same protection against this new strain.

"A third dose will give very good protection I believe," Boura said.

He added that Pfizer and BioNTech are working on a tweaked version of the vaccine that specifically targets Omicron, and that it should be ready by March. He also said that Pfizer's new COVID-19 pill will work against Omicron.

The World Health Organization says Omicron is spreading to more countries in Africa, where it was first detected, and that weekly case counts have "surged by 93%."

However, the WHO also says that hospitalizations "remain low" in South Africa where it was first reported.

"Emerging data from South Africa indicates that Omicron may cause less severe illness," the WHO reported on Thursday.